Ontology highlight
ABSTRACT:
SUBMITTER: Cramer Z
PROVIDER: S-EPMC5976662 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Cramer Zvi Z Sadek Jason J Vazquez Gabriela Galicia GG Di Marco Sergio S Pause Arnim A Pelletier Jerry J Gallouzi Imed-Eddine IE
Scientific reports 20180530 1
Cachexia is a deadly muscle wasting syndrome that arises under conditions linked to chronic inflammation, such as cancer. Cytokines, including interferon γ (IFNγ), tumor necrosis factor α (TNFα) and interleukin-6 (IL-6), and their downstream effectors such as Signal Transducer and Activator of Transcription 3 (STAT3), have been shown to play a prominent role in muscle wasting. Previously, we demonstrated that Pateamine A (PatA), a compound that targets eukaryotic initiation factor 4A (eIF4A), co ...[more]