Ontology highlight
ABSTRACT:
SUBMITTER: Pirruccello-Straub M
PROVIDER: S-EPMC5797207 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Pirruccello-Straub M M Jackson J J Wawersik S S Webster M T MT Salta L L Long K K McConaughy W W Capili A A Boston C C Carven G J GJ Mahanthappa N K NK Turner K J KJ Donovan A A
Scientific reports 20180202 1
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the TGFβ family whose activation requires two proteolytic cleavages to release the growth factor from the prodomain. Specific modulation of myostatin and GDF11 activity by targeting growth factor-receptor interactions has traditionally been challenging. Here we demonstrate that a novel strategy for blocking ...[more]