Ontology highlight
ABSTRACT:
SUBMITTER: Wiegering A
PROVIDER: S-EPMC5978567 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Wiegering Antonia A Dildrop Renate R Kalfhues Lisa L Spychala André A Kuschel Stefanie S Lier Johanna Maria JM Zobel Thomas T Dahmen Stefanie S Leu Tristan T Struchtrup Andreas A Legendre Flora F Vesque Christine C Schneider-Maunoury Sylvie S Saunier Sophie S Rüther Ulrich U Gerhardt Christoph C
The EMBO journal 20180412 10
Ciliopathies are life-threatening human diseases caused by defective cilia. They can often be traced back to mutations of genes encoding transition zone (TZ) proteins demonstrating that the understanding of TZ organisation is of paramount importance. The TZ consists of multimeric protein modules that are subject to a stringent assembly hierarchy. Previous reports place Rpgrip1l at the top of the TZ assembly hierarchy in <i>Caenorhabditis elegans</i> By performing quantitative immunofluorescence ...[more]