Ontology highlight
ABSTRACT:
SUBMITTER: Wang WJ
PROVIDER: S-EPMC3815462 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Wang Won-Jing WJ Tay Hwee Goon HG Soni Rajesh R Perumal Geoffrey S GS Goll Mary G MG Macaluso Frank P FP Asara John M JM Amack Jeffrey D JD Tsou Meng-Fu Bryan MF
Nature cell biology 20130505 6
The transition zone is a specialized compartment found at the base of cilia, adjacent to the centriole distal end, where axonemal microtubules are heavily crosslinked to the surrounding membrane to form a barrier that gates the ciliary compartment. A number of ciliopathy molecules have been found to associate with the transition zone, but factors that directly recognize axonemal microtubules to specify transition zone assembly at the cilia base remain unclear. Here, through quantitative centroso ...[more]