Ontology highlight
ABSTRACT:
SUBMITTER: Aldeghi M
PROVIDER: S-EPMC5978690 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Communications chemistry 20180401
Conserved water molecules are of interest in drug design, as displacement of such waters can lead to higher affinity ligands and in some cases, contribute towards selectivity. Bromodomains, small protein domains involved in the epigenetic regulation of gene transcription, display a network of four conserved water molecules in their binding pockets and have recently been the focus of intense medicinal chemistry efforts. Understanding why certain bromodomains have displaceable water molecules and ...[more]