Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.
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ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC5979323 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Brca1 Is Upregulated by 5-Aza-CdR and Promotes DNA Repair and Cell Survival, and Inhibits Neurite Outgrowth in Rat Retinal Neurons.
Wang Qiyun Q Xu Lijun L Chen Pei P Xu Zhuojun Z Qiu Jin J Ge Jian J Yu Keming K Zhuang Jing J
International journal of molecular sciences 20180417 4
Previous studies have reported that Brca1 acts as a “hinge” in the development of the central nervous system (CNS). However, the precise role of Brca1 in rat retinal neurons remains unclear. Here, we found that Brca1 is developmentally downregulated and silenced in adult retina. Brca1 was upregulated in rat primary retinal neurons by 5-Aza-2′-deoxycytidine (5-Aza-CdR) treatment. Moreover, the upregulation of Brca1 by both 5-Aza-CdR and transgenic Brca1 promoted genomic stabilit ...[more]
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