Ontology highlight
ABSTRACT:
SUBMITTER: Rega C
PROVIDER: S-EPMC5981002 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Rega Camilla C Russo Rosita R Focà Annalia A Sandomenico Annamaria A Iaccarino Emanuela E Raimondo Domenico D Milanetti Edoardo E Tornatore Laura L Franzoso Guido G Pedone Paolo Vincenzo PV Ruvo Menotti M Chambery Angela A
International journal of biological macromolecules 20180320
GADD45β is selectively and constitutively expressed in Multiple Myeloma cells, and this expression correlates with an unfavourable clinical outcome. GADD45β physically interacts with the JNK kinase, MKK7, inhibiting its activity to enable the survival of cancer cells. DTP3 is a small peptide inhibitor of the GADD45β/MKK7 complex and is able to restore MKK7/JNK activation, thereby promoting selective cell death of GADD45β-overexpressing cancer cells. Enzymatic MS foot-printing and diazirine-based ...[more]