Ontology highlight
ABSTRACT:
SUBMITTER: Komori H
PROVIDER: S-EPMC5981219 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Scientific reports 20180531 1
The transcription factor E2F plays crucial roles in cell proliferation and tumor suppression by activating growth-related genes and pro-apoptotic tumor suppressor genes, respectively. It is generally accepted that E2F binds to target sequences with its heterodimeric partner DP. Here we show that, while knockdown of DP1 expression inhibited ectopic E2F1- or adenovirus E1a-induced expression of the CDC6 gene and cell proliferation, knockdown of DP1 and DP2 expression did not affect ectopic E2F1- o ...[more]