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Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.

ABSTRACT: Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2?9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative activity against KB cancer cell lines, but psammaplysene D (1) displayed substantial cytotoxicity as well as acetylcholinesterase inhibition with IC50 values of 0.7 μM and 1.3 μM, respectively.

SUBMITTER: El-Demerdash A

PROVIDER: S-EPMC5983277 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Bioactive Bromotyrosine-Derived Alkaloids from the Polynesian Sponge Suberea ianthelliformis.

El-Demerdash Amr A Moriou Céline C Toullec Jordan J Besson Marc M Soulet Stéphanie S Schmitt Nelly N Petek Sylvain S Lecchini David D Debitus Cécile C Al-Mourabit Ali A

Marine drugs 20180427 5

Herein, we describe the isolation and spectroscopic identification of eight new tetrabrominated tyrosine alkaloids 2⁻9 from the Polynesian sponge Suberea ianthelliformis, along with known major compound psammaplysene D (1), N,N-dimethyldibromotyramine, 5-hydroxy xanthenuric acid, and xanthenuric acid. Cytotoxicity and acetylcholinesterase inhibition activities were evaluated for some of the isolated metabolites. They exhibited moderate antiproliferative ...[more]

PMID: 29702602

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