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Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

ABSTRACT: Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.

SUBMITTER: Park JS

PROVIDER: S-EPMC7824209 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge.

Park Jae Sung JS Cho Eunji E Hwang Ji-Yeon JY Park Sung Chul SC Chung Beomkoo B Kwon Oh-Seok OS Sim Chung J CJ Oh Dong-Chan DC Oh Ki-Bong KB Shin Jongheon J

Marine drugs 20201223 1

Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of ...[more]

PMID: 33374750

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