Ontology highlight
ABSTRACT:
SUBMITTER: Lobysheva E
PROVIDER: S-EPMC5983371 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Lobysheva E E Taylor C M CM Marshall G R GR Kisselev O G OG
Experimental eye research 20180216
The heterotrimeric G-protein binding site on G-protein coupled receptors remains relatively unexplored regarding its potential as a new target of therapeutic intervention or as a secondary site of action by the existing drugs. Tauroursodeoxycholic acid bears structural resemblance to several compounds that were previously identified to specifically bind to the light-activated form of the visual receptor rhodopsin and to inhibit its activation of transducin. We show that TUDCA stabilizes the acti ...[more]