? Cell GLP-1R Signaling Alters ? Cell Proglucagon Processing after Vertical Sleeve Gastrectomy in Mice.

ABSTRACT: Bariatric surgery, such as vertical sleeve gastrectomy (VSG), causes high rates of type 2 diabetes remission and remarkable increases in postprandial glucagon-like peptide-1 (GLP-1) secretion. GLP-1 plays a critical role in islet function by potentiating glucose-stimulated insulin secretion; however, the mechanisms remain incompletely defined. Therefore, we applied a murine VSG model to an inducible ? cell-specific GLP-1 receptor (GLP-1R) knockout mouse model to investigate the role of the ? cell GLP-1R in islet function. Our data show that loss of ? cell GLP-1R signaling decreases ? cell GLP-1 expression after VSG. Furthermore, we find a ? cell GLP-1R-dependent increase in ? cell expression of the prohormone convertase required for the production of GLP-1 after VSG. Together, the findings herein reveal two concepts. First, our data support a paracrine role for ? cell-derived GLP-1 in the metabolic benefits observed after VSG. Second, we have identified a role for the ? cell GLP-1R as a regulator of ? cell proglucagon processing.

SUBMITTER: Garibay D 

PROVIDER: S-EPMC5983903 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature