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NONLINEAR PREDICTIVE LATENT PROCESS MODELS FOR INTEGRATING SPATIO-TEMPORAL EXPOSURE DATA FROM MULTIPLE SOURCES.

ABSTRACT: Spatio-temporal prediction of levels of an environmental exposure is an important problem in environmental epidemiology. Our work is motivated by multiple studies on the spatio-temporal distribution of mobile source, or traffic related, particles in the greater Boston area. When multiple sources of exposure information are available, a joint model that pools information across sources maximizes data coverage over both space and time, thereby reducing the prediction error. We consider a Bayesian hierarchical framework in which a joint model consists of a set of submodels, one for each data source, and a model for the latent process that serves to relate the submodels to one another. If a submodel depends on the latent process nonlinearly, inference using standard MCMC techniques can be computationally prohibitive. The implications are particularly severe when the data for each submodel are aggregated at different temporal scales. To make such problems tractable, we linearize the nonlinear components with respect to the latent process and induce sparsity in the covariance matrix of the latent process using compactly supported covariance functions. We propose an efficient MCMC scheme that takes advantage of these approximations. We use our model to address a temporal change of support problem whereby interest focuses on pooling daily and multiday black carbon readings in order to maximize the spatial coverage of the study region.

SUBMITTER: Bliznyuk N

PROVIDER: S-EPMC5983907 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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NONLINEAR PREDICTIVE LATENT PROCESS MODELS FOR INTEGRATING SPATIO-TEMPORAL EXPOSURE DATA FROM MULTIPLE SOURCES.

Bliznyuk Nikolay N Paciorek Christopher J CJ Schwartz Joel J Coull Brent B

The annals of applied statistics 20140901 3

Spatio-temporal prediction of levels of an environmental exposure is an important problem in environmental epidemiology. Our work is motivated by multiple studies on the spatio-temporal distribution of mobile source, or traffic related, particles in the greater Boston area. When multiple sources of exposure information are available, a joint model that pools information across sources maximizes data coverage over both space and time, thereby reducing the prediction error. We consider a Bayesian ...[more]

PMID: 29861821

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Project description:BackgroundBayesian models have been applied throughout the Covid-19 pandemic especially to model time series of case counts or deaths. Fewer examples exist of spatio-temporal modeling, even though the spatial spread of disease is a crucial factor in public health monitoring. The predictive capabilities of infectious disease models is also important.MethodsIn this study, the ability of Bayesian hierarchical models to recover different parts of the variation in disease counts is the focus. It is clear that different measures provide different views of behavior when models are fitted prospectively. Over a series of time horizons one step predictions have been generated and compared for different models (for case counts and death counts). These Bayesian SIR models were fitted using MCMC at 28 time horizons to mimic prospective prediction. A range of goodness of prediction measures were analyzed across the different time horizons.ResultsA particularly important result is that the peak intensity of case load is often under-estimated, while random spikes in case load can be mimicked using time dependent random effects. It is also clear that during the early wave of the pandemic simpler model forms are favored, but subsequently lagged spatial dependence models for cases are favored, even if the sophisticated models perform better overall.DiscussionThe models fitted mimic the situation where at a given time the history of the process is known but the future must be predicted based on the current evolution which has been observed. Using an overall 'best' model for prediction based on retrospective fitting of the complete pandemic waves is an assumption. However it is also clear that this case count model is well favored over other forms. During the first wave a simpler time series model predicts case counts better for counties than a spatially dependent one. The picture is more varied for morality.ConclusionsFrom a predictive point of view it is clear that spatio-temporal models applied to county level Covid-19 data within the US vary in how well they fit over time and also how well they predict future events. At different times, SIR case count models and also mortality models with cumulative counts perform better in terms of prediction. A fundamental result is that predictive capability of models varies over time and using the same model could lead to poor predictive performance. In addition it is clear that models addressing the spatial context for case counts (i.e. with lagged neighborhood terms) and cumulative case counts for mortality data are clearly better at modeling spatio-temporal data which is commonly available for the Covid-19 pandemic in different areas of the globe.

Project description:Often, in environmental data collection, data arise from two sources: numerical models and monitoring networks. The first source provides predictions at the level of grid cells, while the second source gives measurements at points. The first is characterized by full spatial coverage of the region of interest, high temporal resolution, no missing data but consequential calibration concerns. The second tends to be sparsely collected in space with coarser temporal resolution, often with missing data but, where recorded, provides, essentially, the true value. Accommodating the spatial misalignment between the two types of data is of fundamental importance for both improved predictions of exposure as well as for evaluation and calibration of the numerical model. In this article we propose a simple, fully model-based strategy to downscale the output from numerical models to point level. The static spatial model, specified within a Bayesian framework, regresses the observed data on the numerical model output using spatially-varying coefficients which are specified through a correlated spatial Gaussian process.As an example, we apply our method to ozone concentration data for the eastern U.S. and compare it to Bayesian melding (Fuentes and Raftery 2005) and ordinary kriging (Cressie 1993; Chilès and Delfiner 1999). Our results show that our method outperforms Bayesian melding in terms of computing speed and it is superior to both Bayesian melding and ordinary kriging in terms of predictive performance; predictions obtained with our method are better calibrated and predictive intervals have empirical coverage closer to the nominal values. Moreover, our model can be easily extended to accommodate for the temporal dimension. In this regard, we consider several spatio-temporal versions of the static model. We compare them using out-of-sample predictions of ozone concentration for the eastern U.S. for the period May 1-October 15, 2001. For the best choice, we present a summary of the analysis. Supplemental material, including color versions of Figures 4, 5, 6, 7, and 8, and MCMC diagnostic plots, are available online.

Dataset Information

NONLINEAR PREDICTIVE LATENT PROCESS MODELS FOR INTEGRATING SPATIO-TEMPORAL EXPOSURE DATA FROM MULTIPLE SOURCES.

Publications

NONLINEAR PREDICTIVE LATENT PROCESS MODELS FOR INTEGRATING SPATIO-TEMPORAL EXPOSURE DATA FROM MULTIPLE SOURCES.

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