PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.
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ABSTRACT:
SUBMITTER: Heinrich MC
PROVIDER: S-EPMC5984312 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.
Heinrich Marie-Christine MC Göbel Cosima C Kluth Martina M Bernreuther Christian C Sauer Charlotte C Schroeder Cornelia C Möller-Koop Christina C Hube-Magg Claudia C Lebok Patrick P Burandt Eike E Sauter Guido G Simon Ronald R Huland Hartwig H Graefen Markus M Heinzer Hans H Schlomm Thorsten T Heumann Asmus A
BMC cancer 20180531 1
<h4>Background</h4>Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.<h4>Methods</h4>To clarify contradictory findings on the prognostic role of PSCA expression, a tissue microarray containing 13,665 prostate cancers was analyzed by immunohistochemistry.<h4>Results</h4>PSCA staining was absent in normal epithelial and stromal cells of the prostate. Membranous and cytoplasmic PSCA staining was seen in 53.7% of 9642 interpretable tumors. ...[more]
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