Ontology highlight
ABSTRACT:
SUBMITTER: Pan JX
PROVIDER: S-EPMC5984632 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Bone research 20180601
YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo pathway, a conserved pathway for the development and size control of multiple organs. The exact function of YAP in bone homeostasis remains controversial. Here we provide evidence for YAP's function in promoting osteogenesis, suppressing adipogenesis, and thus maintaining bone homeostasis. YAP is selectively expressed in osteoblast (OB)-lineage cells. Conditionally knocking out <i>Yap</i> in the OB lin ...[more]