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Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study.
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ABSTRACT: Background
Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for young patients.Methods
We performed a comprehensive search of the Surveillance, Epidemiology, and End Results (SEER) database, 2360 CC patients aged from 20 to 40 were analyzed. X-tile was used to determine the optimal cut-off point of lymph node based on survival outcomes of young patients. The cancer specific survival (CSS) was estimated with Kaplan-Meier method, the Cox proportional hazards regression model was used to analyse independent prognostic factors and exact 95% confidence intervals (CIs).Results
Using X-tile analysis, 22-node measure was identified as the optimal choice for CC patients aged ConclusionsFor young colon cancer patients, the lymph node examination should be differently evaluated. We suggest that 22-node measure may be more suitable for CC patients aged Trial registrationRetrospectively registered.
SUBMITTER: Guan X
PROVIDER: S-EPMC5984774 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
Reconsideration of the optimal minimum lymph node count for young colon cancer patients: a population-based study.
BMC cancer 20180601 1
<h4>Background</h4>Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for young patients.<h4>Methods</h4>We performed a comprehensive search of the Surveillance, Epidemiology, and End Results (SEER) database, 2360 CC patients aged from 20 to 40 were analyzed. X-tile was used to determine the optimal cut-off point of lymph node based on survival o ...[more]