How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels.
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ABSTRACT:
SUBMITTER: Silva JR
PROVIDER: S-EPMC5984968 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Publications
How to Connect Cardiac Excitation to the Atomic Interactions of Ion Channels.
Biophysical journal 20180101 2
Many have worked to create cardiac action potential models that explicitly represent atomic-level details of ion channel structure. Such models have the potential to define new therapeutic directions and to show how nanoscale perturbations to channel function predispose patients to deadly cardiac arrhythmia. However, there have been significant experimental and theoretical barriers that have limited model usefulness. Recently, many of these barriers have come down, suggesting that considerable p ...[more]
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