Ontology highlight
ABSTRACT:
SUBMITTER: Chrzanowski SM
PROVIDER: S-EPMC5985549 | biostudies-literature | 2017 Jan-Dec
REPOSITORIES: biostudies-literature
Chrzanowski Stephen M SM Vohra Ravneet S RS Lee-McMullen Brittany A BA Batra Abhinandan A Spradlin Ray A RA Morales Jazmine J Forbes Sean S Vandenborne Krista K Barton Elisabeth R ER Walter Glenn A GA
Molecular imaging 20170101
Assessment of muscle pathology is a key outcome measure to measure the success of clinical trials studying muscular dystrophies; however, few robust minimally invasive measures exist. Indocyanine green (ICG)-enhanced near-infrared (NIR) optical imaging offers an objective, minimally invasive, and longitudinal modality that can quantify pathology within muscle by imaging uptake of ICG into the damaged muscles. Dystrophic mice lacking dystrophin (mdx) or gamma-sarcoglycan (Sgcg<sup>-/-</sup>) were ...[more]