Ontology highlight
ABSTRACT:
SUBMITTER: Kamariza M
PROVIDER: S-EPMC5985656 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Kamariza Mireille M Shieh Peyton P Ealand Christopher S CS Peters Julian S JS Chu Brian B Rodriguez-Rivera Frances P FP Babu Sait Mohammed R MR Babu Sait Mohammed R MR Treuren William V WV Martinson Neil N Kalscheuer Rainer R Kana Bavesh D BD Bertozzi Carolyn R CR
Science translational medicine 20180201 430
Tuberculosis (TB) is the leading cause of death from an infectious bacterial disease. Poor diagnostic tools to detect active disease plague TB control programs and affect patient care. Accurate detection of live <i>Mycobacterium tuberculosis</i> (Mtb), the causative agent of TB, could improve TB diagnosis and patient treatment. We report that mycobacteria and other corynebacteria can be specifically detected with a fluorogenic trehalose analog. We designed a 4-<i>N,N</i>-dimethylamino-1,8-naphth ...[more]