Ontology highlight
ABSTRACT:
SUBMITTER: Wong NML
PROVIDER: S-EPMC5985775 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Wong Nicole M L NML Wong Wilson W WW
ACS synthetic biology 20180402 4
T cells expressing tumor-specific T cell receptors are promising cancer therapeutic agents, but safety control switches are needed to manage potential side effects arising from overactivity. Here, we present the first dual small molecule-gated ZAP70 signaling switch for the regulation of T cell activity. We show that when an analogue-sensitive ZAP70 allele is fused to the engineered ligand binding domain of the estrogen receptor, ER<sup>T2</sup>, its activity can be upregulated to an extent by a ...[more]