Ontology highlight
ABSTRACT:
SUBMITTER: de Graffenried CL
PROVIDER: S-EPMC534710 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
de Graffenried Christopher L CL Laughlin Scott T ST Kohler Jennifer J JJ Bertozzi Carolyn R CR
Proceedings of the National Academy of Sciences of the United States of America 20041117 48
The study of glycan function is a major frontier in biology that could benefit from small molecules capable of perturbing carbohydrate structures on cells. The widespread role of sulfotransferases in modulating glycan function makes them prime targets for small-molecule modulators. Here, we report a system for conditional activation of Golgi-resident sulfotransferases using a chemical inducer of dimerization. Our approach capitalizes on two features shared by these enzymes: their requirement of ...[more]