Ontology highlight
ABSTRACT:
SUBMITTER: Luciano M
PROVIDER: S-EPMC5985926 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Nature genetics 20171218 1
Neuroticism is a relatively stable personality trait characterized by negative emotionality (for example, worry and guilt) <sup>1</sup> ; heritability estimated from twin studies ranges from 30 to 50% <sup>2</sup> , and SNP-based heritability ranges from 6 to 15% <sup>3-6</sup> . Increased neuroticism is associated with poorer mental and physical health <sup>7,8</sup> , translating to high economic burden <sup>9</sup> . Genome-wide association studies (GWAS) of neuroticism have identified up to ...[more]