Ontology highlight
ABSTRACT:
SUBMITTER: Oganesyan V
PROVIDER: S-EPMC5986207 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Oganesyan Vaheh V Peng Li L Bee Jared S JS Li John J Perry Samuel R SR Comer Frank F Xu Linda L Cook Kimberly K Senthil Kannaki K Clarke Lori L Rosenthal Kim K Gao Changshou C Damschroder Melissa M Wu Herren H Dall'Acqua William W
The Journal of biological chemistry 20180418 22
Pathways of human epidermal growth factor (EGF) receptors are activated upon ligand-dependent or -independent homo- or heterodimerization and their subsequent transphosphorylation. Overexpression of these receptors positively correlates with transphosphorylation rates and increased tumor growth rates. MEDI4276, an anti-human epidermal growth factor receptor 2 (HER2) biparatopic antibody-drug conjugate, has two paratopes within each antibody arm. One, 39S, is aiming at the HER2 site involved in r ...[more]