Ontology highlight
ABSTRACT:
SUBMITTER: Peng L
PROVIDER: S-EPMC5098442 | biostudies-literature | 2016 Nov/Dec
REPOSITORIES: biostudies-literature
Peng Li L Cook Kimberly K Xu Linda L Cheng Li L Damschroder Melissa M Gao Changshou C Wu Herren H Dall'Acqua William F WF
mAbs 20160909 8
Inhibitors of tumor necrosis factor-α converting enzyme (TACE) have potential as therapeutics for various diseases. Many small molecule inhibitors, however, exhibit poor specificity profiles because they target the highly conserved catalytic cleft of TACE. We report for the first time the molecular interaction of a highly specific anti-TACE antagonistic antibody (MEDI3622). We characterized the binding of MEDI3622 using mutagenesis, as well as structural modeling and docking approaches. We show ...[more]