Ontology highlight
ABSTRACT:
SUBMITTER: Weinhaupl K
PROVIDER: S-EPMC5986217 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Weinhäupl Katharina K Brennich Martha M Kazmaier Uli U Lelievre Joel J Ballell Lluis L Goldberg Alfred A Schanda Paul P Fraga Hugo H
The Journal of biological chemistry 20180409 22
<i>Mycobacterium tuberculosis</i> can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill <i>Mycobacterium tuberculosis</i> persisters. Their target is the N-terminal domain of the hexameric AAA+ ATPase ClpC1, which recognizes, unfolds, and translocates protein substrates, such as proteins containing phosphorylated arginine residues, to the ...[more]