Ontology highlight
ABSTRACT:
SUBMITTER: Karlsson CAQ
PROVIDER: S-EPMC5986240 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Karlsson Christofer A Q CAQ Järnum Sofia S Winstedt Lena L Kjellman Christian C Björck Lars L Linder Adam A Malmström Johan A JA
Molecular & cellular proteomics : MCP 20180306 6
Infectious diseases are characterized by a complex interplay between host and pathogen, but how these interactions impact the host proteome is unclear. Here we applied a combined mass spectrometry-based proteomics strategy to investigate how the human proteome is transiently modified by the pathogen <i>Streptococcus pyogenes</i>, with a particular focus on bacterial cleavage of IgG <i>in vivo</i> In invasive diseases, <i>S. pyogenes</i> evokes a massive host response in blood, whereas superficia ...[more]