Ontology highlight
ABSTRACT:
SUBMITTER: Reglinski M
PROVIDER: S-EPMC4623672 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Reglinski Mark M Gierula Magdalena M Lynskey Nicola N NN Edwards Robert J RJ Sriskandan Shiranee S
Scientific reports 20151028
Immunity to common bacteria requires the generation of antibodies that promote opsonophagocytosis and neutralise toxins. Pooled human immunoglobulin is widely advocated as an adjunctive treatment for clinical Streptococcus pyogenes infection however, the protein targets of the reagent remain ill defined. Affinity purification of the anti-streptococcal antibodies present within pooled immunoglobulin resulted in the generation of an IgG preparation that promoted opsonophagocytic killing of S. pyog ...[more]