Dataset Information

Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project.

ABSTRACT: Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary habits and lifestyle with gut microbiota. Stool samples from 248 citizen-science volunteers were collected before and after a self-reported 2-week personalized diet intervention, then analyzed using 16S rRNA sequencing. Considerable correlations between long-term dietary habits and gut community structure were detected. A higher intake of vegetables and fruits was associated with increased levels of butyrate-producing Clostridiales and higher community richness. A paired comparison of the metagenomes before and after the 2-week intervention showed that even a brief, uncontrolled intervention produced profound changes in community structure: resulting in decreased levels of Bacteroidaceae, Porphyromonadaceae and Rikenellaceae families and decreased alpha-diversity coupled with an increase of Methanobrevibacter, Bifidobacterium, Clostridium and butyrate-producing Lachnospiraceae- as well as the prevalence of a permatype (a bootstrapping-based variation of enterotype) associated with a higher diversity of diet. The response of microbiota to the intervention was dependent on the initial microbiota state. These findings pave the way for the development of an individualized diet.

SUBMITTER: Klimenko NS

PROVIDER: S-EPMC5986456 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project.

Klimenko Natalia S NS Tyakht Alexander V AV Popenko Anna S AS Vasiliev Anatoly S AS Altukhov Ilya A IA Ischenko Dmitry S DS Shashkova Tatiana I TI Efimova Daria A DA Nikogosov Dmitri A DA Osipenko Dmitrii A DA Musienko Sergey V SV Selezneva Kseniya S KS Baranova Ancha A Kurilshikov Alexander M AM Toshchakov Stepan M SM Korzhenkov Aleksei A AA Samarov Nazar I NI Shevchenko Margarita A MA Tepliuk Alina V AV Alexeev Dmitry G DG

Nutrients 20180508 5

Personalized nutrition is of increasing interest to individuals actively monitoring their health. The relations between the duration of diet intervention and the effects on gut microbiota have yet to be elucidated. Here we examined the associations of short-term dietary changes, long-term dietary habits and lifestyle with gut microbiota. Stool samples from 248 citizen-science volunteers were collected before and after a self-reported 2-week personalized diet intervention, then analyzed using 16S ...[more]

PMID: 29738477

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Dataset Information

Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project.

Publications

Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project.

Similar Datasets

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