Ontology highlight
ABSTRACT:
SUBMITTER: Kaneko MK
PROVIDER: S-EPMC5986659 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Kaneko Mika K MK Yamada Shinji S Itai Shunsuke S Chang Yao-Wen YW Nakamura Takuro T Yanaka Miyuki M Kato Yukinari Y
Biochemistry and biophysics reports 20180412
The epidermal growth factor receptor (EGFR) is a type-1 transmembrane receptor tyrosine kinase, which activates the downstream signaling cascades in many tumors, such as oral and lung cancers. We previously developed EMab-134, a novel anti-EGFR monoclonal antibody (mAb), which reacts with endogenous EGFR-expressing cancer cell lines and normal cells independent of glycosylation in Western blotting, flow cytometry, and immunohistochemical analysis. EMab-134 showed very high sensitivity (94.7%) to ...[more]