Ontology highlight
ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC5986771 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cell discovery 20180605
The re-emergence of Zika virus (ZIKV) and Ebola virus (EBOV) poses serious and continued threats to the global public health. Effective therapeutics for these maladies is an unmet need. Here, we show that emetine, an anti-protozoal agent, potently inhibits ZIKV and EBOV infection with a low nanomolar half maximal inhibitory concentration (IC<sub>50</sub>) in vitro and potent activity in vivo. Two mechanisms of action for emetine are identified: the inhibition of ZIKV NS5 polymerase activity and ...[more]