Ontology highlight
ABSTRACT:
SUBMITTER: Tchourine K
PROVIDER: S-EPMC5987223 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Tchourine Konstantine K Vogel Christine C Bonneau Richard R
Cell reports 20180401 2
Large-scale inference of eukaryotic transcription-regulatory networks remains challenging. One underlying reason is that existing algorithms typically ignore crucial regulatory mechanisms, such as RNA degradation and post-transcriptional processing. Here, we describe InfereCLaDR, which incorporates such elements and advances prediction in Saccharomyces cerevisiae. First, InfereCLaDR employs a high-quality Gold Standard dataset that we use separately as prior information and for model validation. ...[more]