Ontology highlight
ABSTRACT:
SUBMITTER: Sumigray KD
PROVIDER: S-EPMC5987226 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sumigray Kaelyn D KD Terwilliger Michael M Lechler Terry T
Developmental cell 20180401 2
The adult mammalian intestine is composed of two connected structures, the absorptive villi and the crypts, which house progenitor cells. Mouse crypts develop postnatally and are the architectural unit of the stem cell niche, yet the pathways that drive their formation are not known. Here, we combine transcriptomic, quantitative morphometric, and genetic analyses to identify mechanisms of crypt development. We uncover the upregulation of a contractility gene network at the earliest stage of cryp ...[more]