Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Gonzalez C
PROVIDER: S-EPMC7611697 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Pérez-González Carlos C Ceada Gerardo G Greco Francesco F Matejčić Marija M Gómez-González Manuel M Castro Natalia N Menendez Anghara A Kale Sohan S Krndija Denis D Clark Andrew G AG Gannavarapu Venkata Ram VR Álvarez-Varela Adrián A Roca-Cusachs Pere P Batlle Eduard E Vignjevic Danijela Matic DM Arroyo Marino M Trepat Xavier X
Nature cell biology 20210621 7
Intestinal organoids capture essential features of the intestinal epithelium such as crypt folding, cellular compartmentalization and collective movements. Each of these processes and their coordination require patterned forces that are at present unknown. Here we map three-dimensional cellular forces in mouse intestinal organoids grown on soft hydrogels. We show that these organoids exhibit a non-monotonic stress distribution that defines mechanical and functional compartments. The stem cell co ...[more]