Ontology highlight
ABSTRACT:
SUBMITTER: Saegusa K
PROVIDER: S-EPMC5987718 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
The Journal of cell biology 20180411 6
Lipoproteins regulate the overall lipid homeostasis in animals. However, the molecular mechanisms underlying lipoprotein trafficking remain poorly understood. Here, we show that SFT-4, a <i>Caenorhabditis elegans</i> homologue of the yeast Erv29p, is essential for the endoplasmic reticulum (ER) export of the yolk protein VIT-2, which is synthesized as a lipoprotein complex. SFT-4 loss strongly inhibits the ER exit of yolk proteins and certain soluble cargo proteins in intestinal cells. SFT-4 pre ...[more]