Ontology highlight
ABSTRACT:
SUBMITTER: Su L
PROVIDER: S-EPMC6463267 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
The EMBO journal 20190311 8
SREBPs are master regulators of lipid homeostasis and undergo sterol-regulated export from ER to Golgi apparatus for processing and activation via COPII-coated vesicles. While COPII recognizes SREBP through its escort protein SCAP, factor(s) specifically promoting SREBP/SCAP loading to the COPII machinery remains unknown. Here, we show that the ER/lipid droplet-associated protein Cideb selectively promotes the loading of SREBP/SCAP into COPII vesicles. Sterol deprivation releases SCAP from Insig ...[more]