Ontology highlight
ABSTRACT:
SUBMITTER: Turan T
PROVIDER: S-EPMC5989400 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Turan Tolga T Kannan Deepti D Patel Maulik M Matthew Barnes J J Tanlimco Sonia G SG Lu Rongze R Halliwill Kyle K Kongpachith Sarah S Kline Douglas E DE Hendrickx Wouter W Cesano Alessandra A Butterfield Lisa H LH Kaufman Howard L HL Hudson Thomas J TJ Bedognetti Davide D Marincola Francesco F Samayoa Josue J
Journal for immunotherapy of cancer 20180605 1
Anti-cancer immunotherapy is encountering its own checkpoint. Responses are dramatic and long lasting but occur in a subset of tumors and are largely dependent upon the pre-existing immune contexture of individual cancers. Available data suggest that three landscapes best define the cancer microenvironment: immune-active, immune-deserted and immune-excluded. This trichotomy is observable across most solid tumors (although the frequency of each landscape varies depending on tumor tissue of origin ...[more]