Ontology highlight
ABSTRACT:
SUBMITTER: DiNardo AR
PROVIDER: S-EPMC7260034 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
DiNardo Andrew R AR Rajapakshe Kimal K Nishiguchi Tomoki T Grimm Sandra L SL Mtetwa Godwin G Dlamini Qiniso Q Kahari Jaqueline J Mahapatra Sanjana S Kay Alexander A Maphalala Gugu G Mace Emily M EM Makedonas George G Cirillo Jeffrey D JD Netea Mihai G MG van Crevel Reinout R Coarfa Cristian C Mandalakas Anna M AM
The Journal of clinical investigation 20200601 6
Mycobacterium tuberculosis (M. tuberculosis) has coevolved with humans for millennia and developed multiple mechanisms to evade host immunity. Restoring host immunity in order to improve outcomes and potentially shorten existing therapy will require identification of the full complement by which host immunity is inhibited. Perturbation of host DNA methylation is a mechanism induced by chronic infections such as HIV, HPV, lymphocytic choriomeningitis virus (LCMV), and schistosomiasis to evade hos ...[more]