Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.
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ABSTRACT:
SUBMITTER: Cunden LS
PROVIDER: S-EPMC5989567 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
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Bioinorganic Explorations of Zn(II) Sequestration by Human S100 Host-Defense Proteins.
Cunden Lisa S LS Nolan Elizabeth M EM
Biochemistry 20180306 11
The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II ...[more]
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