Ontology highlight
ABSTRACT:
SUBMITTER: Gu H
PROVIDER: S-EPMC5989658 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Gu Hao H Do Dang Vinh DV Liu Xinyu X Xu Luang L Su Yixun Y Nah Jie Min JM Wong Yuqian Y Li Ying Y Sheng Na N Tilaye Gebreselassie Addisu GA Yang Henry H Guo Huili H Yan Jun J Fu Xin-Yuan XY
Stem cell reports 20180426 6
The capacity of embryonic stem cells (ESCs) to differentiate into all lineages of mature organism is precisely regulated by cellular signaling factors. STAT3 is a crucial transcription factor that plays a central role in maintaining ESC identity. However, the underlying mechanism by which STAT3 directs differentiation is still not completely understood. Here, we show that STAT3 positively regulates gene expression of methyltransferase-like protein 8 (Mettl8) in mouse ESCs. We found that METTL8 i ...[more]