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The pancreatic cancer microenvironment: A true double agent.

ABSTRACT: The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The developing clinical therapeutics will be reviewed.

SUBMITTER: Melstrom LG

PROVIDER: S-EPMC5989710 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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The pancreatic cancer microenvironment: A true double agent.

Melstrom Laleh G LG Salazar Marcela D MD Diamond Don J DJ

Journal of surgical oncology 20170612 1

The tumor microenvironment in pancreatic cancer is a complex balance of pro- and anti-tumor components. The dense desmoplasia consists of immune cells, extracellular matrix, growth factors, cytokines, and cancer associated fibroblasts (CAF) or pancreatic stellate cells (PSC). There are a multitude of targets including hyaluronan, angiogenesis, focal adhesion kinase (FAK), connective tissue growth factor (CTGF), CD40, chemokine (C-X-C motif) receptor 4 (CXCR-4), immunotherapy, and Vitamin D. The ...[more]

PMID: 28605029

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