Ontology highlight
ABSTRACT:
SUBMITTER: Sun S
PROVIDER: S-EPMC5989839 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Sun Si S Zhao Simei S Yang Qiang Q Wang Wenwen W Cai E E Wen Yiping Y Yu Lili L Wang Zehua Z Cai Jing J
Cancer science 20180515 6
Enhancer of zeste homolog 2 (EZH2), which is overexpressed in a wide range of tumors, contributes to ovarian cancer malignancy in several different ways. We aimed to illustrate the role of EZH2 in ovarian cancer cisplatin resistance and to identify possible underlying mechanisms of this role that may provide a rationale for targeting EZH2 in cancer treatment. Here, we present data indicating that EZH2 overexpression is associated with cisplatin resistance and intracellular platinum drug accumula ...[more]