Ontology highlight
ABSTRACT:
SUBMITTER: Nakagawa M
PROVIDER: S-EPMC6113435 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nakagawa Makoto M Kitabayashi Issay I
Cancer science 20180627 8
Polycomb group (PcG) proteins regulate the expression of target genes by modulating histone modifications and are representative epigenetic regulators that maintain the stemness of embryonic and hematopoietic stem cells. Histone methyltransferases enhancer of zeste homolog 1 and 2 (EZH1/2), which are subunits of polycomb repressive complexes (PRC), are recurrently mutated or highly expressed in many hematological malignancies. EZH2 has a dual function in tumorigenesis as an oncogene and tumor su ...[more]