Ontology highlight
ABSTRACT:
SUBMITTER: Munoz M
PROVIDER: S-EPMC5989924 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Muñoz María M Pong-Wong Ricardo R Canela-Xandri Oriol O Rawlik Konrad K Haley Chris S CS Tenesa Albert A
Nature genetics 20160718 9
Genome-wide association studies have detected many loci underlying susceptibility to disease, but most of the genetic factors that contribute to disease susceptibility remain unknown. Here we provide evidence that part of the 'missing heritability' can be explained by an overestimation of heritability. We estimated the heritability of 12 complex human diseases using family history of disease in 1,555,906 individuals of white ancestry from the UK Biobank. Estimates using simple family-based stati ...[more]