Ontology highlight
ABSTRACT:
SUBMITTER: Espuny-Camacho I
PROVIDER: S-EPMC5990494 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Espuny-Camacho Ira I Michelsen Kimmo A KA Linaro Daniele D Bilheu Angéline A Acosta-Verdugo Sandra S Herpoel Adèle A Giugliano Michele M Gaillard Afsaneh A Vanderhaeghen Pierre P
Cell reports 20180501 9
The transplantation of pluripotent stem-cell-derived neurons constitutes a promising avenue for the treatment of several brain diseases. However, their potential for the repair of the cerebral cortex remains unclear, given its complexity and neuronal diversity. Here, we show that human visual cortical cells differentiated from embryonic stem cells can be transplanted and can integrate successfully into the lesioned mouse adult visual cortex. The transplanted human neurons expressed the appropria ...[more]