Ontology highlight
ABSTRACT:
SUBMITTER: Ambrogini E
PROVIDER: S-EPMC5990540 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Ambrogini Elena E Que Xuchu X Wang Shuling S Yamaguchi Fumihiro F Weinstein Robert S RS Tsimikas Sotirios S Manolagas Stavros C SC Witztum Joseph L JL Jilka Robert L RL
Nature communications 20180606 1
Atherosclerosis and osteoporosis are epidemiologically linked and oxidation specific epitopes (OSEs), such as phosphocholine (PC) of oxidized phospholipids (PC-OxPL) and malondialdehyde (MDA), are pathogenic in both. The proatherogenic effects of OSEs are opposed by innate immune antibodies. Here we show that high-fat diet (HFD)-induced bone loss is attenuated in mice expressing a single chain variable region fragment of the IgM E06 (E06-scFv) that neutralizes PC-OxPL, by increasing osteoblast n ...[more]