Ontology highlight
ABSTRACT:
SUBMITTER: Binder CJ
PROVIDER: S-EPMC7097710 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Binder Christoph J CJ Papac-Milicevic Nikolina N Witztum Joseph L JL
Nature reviews. Immunology 20160627 8
Ageing, infections and inflammation result in oxidative stress that can irreversibly damage cellular structures. The oxidative damage of lipids in membranes or lipoproteins is one of these deleterious consequences that not only alters lipid function but also leads to the formation of neo-self epitopes - oxidation-specific epitopes (OSEs) - which are present on dying cells and damaged proteins. OSEs represent endogenous damage-associated molecular patterns that are recognized by pattern recogniti ...[more]