Targeting BCL-2 regulated apoptosis in cancer.
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ABSTRACT:
SUBMITTER: Campbell KJ
PROVIDER: S-EPMC5990650 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Publications
Targeting BCL-2 regulated apoptosis in cancer.
Campbell Kirsteen J KJ Tait Stephen W G SWG
Open biology 20180501 5
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death during development and maintains organismal health. When unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate tumour development and resistance to cancer therapy. Here we discuss the BCL-2 family, their deregulation in cancer ...[more]
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