Global population-level association between herpes simplex virus 2 prevalence and HIV prevalence.

ABSTRACT: BACKGROUND:Our objective was to assess the population-level association between herpes simplex virus 2 (HSV-2) and HIV prevalence. METHODS:Reports of HSV-2 and HIV prevalence were systematically reviewed and synthesized following PRISMA guidelines. Spearman rank correlation ((Equation is included in full-text article.)) was used to assess correlations. Risk ratios (RRHSV-2/HIV) and odds ratios (ORHSV-2/HIV) were used to assess HSV-2/HIV epidemiologic overlap. DerSimonian-Laird random-effects meta-analyses were conducted. RESULTS:In total, 939 matched HSV-2/HIV prevalence measures were identified from 77 countries. HSV-2 prevalence was consistently higher than HIV prevalence. Strong HSV-2/HIV prevalence association was found for all data ((Equation is included in full-text article.)?=?0.6, P?

SUBMITTER: Kouyoumjian SP 

PROVIDER: S-EPMC5991180 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature