Benefits and harms of lung cancer screening in HIV-infected individuals with CD4+ cell count at least 500 cells/μl.

ABSTRACT: OBJECTIVE:Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals. DESIGN:We modified an existing simulation model, the Lung Cancer Policy Model, for HIV-infected patients. DATA SOURCES:Veterans Aging Cohort Study, Kaiser Permanente Northern California HIV Cohort, and medical literature. TARGET POPULATION:HIV-infected current and former smokers. TIME HORIZON:Lifetime. PERSPECTIVE:Population. INTERV

SUBMITTER: Kong CY 

PROVIDER: S-EPMC5991188 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature