Ablation of somatostatin cells leads to impaired pancreatic islet function and neonatal death in rodents.

ABSTRACT: The somatostatin (SST)-secreting cells were mainly distributed in the pancreatic islets, brain, stomach and intestine in mammals and have many physiological functions. In particular, the SST-secreting δ cell is the third most common cell type in the islets of Langerhans. Recent studies have suggested that dysregulation of paracrine interaction between the pancreatic δ cells and β cells results in impaired glucose homeostasis and contributes to diabetes development. However, direct evidence of the functional importance of SST cells in glucose homeostasis control is still lacking. In the present study, we specifically ablated SST-secreting cells by crossing Sst-cre transgenic mice with R26 ^DTA mice (Sst ^Cre R26 ^DTA ). The Sst ^Cre R26 ^DTA

SUBMITTER: Li N 

PROVIDER: S-EPMC5992210 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature